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Based on interviews with 18 of the world's leading parasitologists and epidemiologists, the stories of their contributions to discovery in contemporary parasitology and infectious disease biology are told. Taken together, the essays prov This series of entertaining essays provides a unique insight into some of the key discoveries that have shaped the field of parasitology.

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Taken together, the essays provide a historical account of the development of the field, serving as a bridge between these discoveries and current research. The book provides a real insight into the thought processes and approaches taken in generating break through scientific discoveries, ranging from immunology to ecology and from malaria and trypanosomiasis to schistosomiasis and Lyme disease.

This engaging and lively introduction to discovery in parasitology will be of interest to all those currently working in the field and will also serve to set the scene for future generations of parasitologists. Get A Copy.

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Hardcover , pages. Published June 1st by Cambridge University Press. More Details Original Title. Other Editions 2. Friend Reviews. To see what your friends thought of this book, please sign up. To ask other readers questions about Parasites and Infectious Disease , please sign up. Be the first to ask a question about Parasites and Infectious Disease. Lists with This Book. This book is not yet featured on Listopia. Community Reviews. Showing Rating details. All Languages. More filters. Sort order. Nobo-ok rated it it was amazing Nov 10, One of them is the prospect of disease elimination.

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  • To date, only smallpox has been eradicated, with guinea worm infection dracunculiasis expected to follow soon. However, with expanded use of the rapid impact package, together with new control tools coming online including hopefully some of our antipoverty vaccines , it might be possible to consider elimination of many of the NTDs discussed here I also believe that how we collaborate and scientifically develop the new antipoverty vaccines may become as important as the vaccines themselves.

    Over the last decade, there has been a greatly expanded capability of developing country vaccine manufacturers to produce new vaccines, such as the one developed by the Serum Institute of India to prevent meningococcal A infection in Africa In some cases, Sabin or other PDPs could be required to collaborate with nations that ideologically contrast with the United States yet have vaccine development capabilities nations such as Cuba or Iran, for instance.

    It will be interesting to see how vaccine diplomacy can enhance U.

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    Tony and the Laboratory of Medical Biochemistry at Rockefeller University provided me with an amazing skill set and knowledge base to tackle NTDs on many different levels and dimensions. I am forever grateful to Tony Cerami for his mentorship and wisdom. The authors declare that they have no competing interests as defined by Molecular Medicine , or other interests that might be perceived to influence the results and discussion reported in this paper. You do not have permission under this license to share adapted material derived from this article or parts of it. Skip to main content Skip to sections.

    Advertisement Hide. Download PDF. The Medical Biochemistry of Poverty and Neglect. Open Access. First Online: 16 December Beginnings One of the happiest memories from my early 20s was returning on the train from New York on a winter evening in Kenneth Warren — 2 , 4. The emphasis was on parasitic infections that plagued people living in poverty.

    ParaSites Project

    Ultimately, the activities of these molecular parasitology units would be integrated into a GND network that would meet regularly in Woods Hole or elsewhere Figure 1 2 , 4. In addition to an extraordinary track record of scientific productivity and international scientific collaboration, the GND program and network trained an entire generation of scientists committed to tropical infections, many of whom remain close colleagues. Open image in new window.

    The human hookworm vaccine currently under development is comprised of two recombinant antigens, each encoding a hookworm Necator americanus enzyme used for the parasite to successfully feed on host blood 7. Thus, some 30 years after the concept was proposed, the first human hookworm vaccine is in clinical trials in Brazil, with plans to expand clinical testing to Gabon in sub-Saharan Africa. MMRF is also helping us to expand the coverage and disease targets of the hookworm vaccine to include all three major intestinal worm infections—ascariasis, trichuriasis and hookworm infection 8 , and possibly schistosomiasis as well Figure 2 9.

    Figure 2 A multivalent vaccine could target all three soil-transmitted helminths and schistosomiasis. Our funding comes from a variety of sources including those mentioned above, as well as the Carlos Slim Health Institute, the U. Google Scholar. Esch GW. Prologue, [portion of prologue on Peter Hotez]; pp.

    Parasites and Infectious Disease: Discovery by Serendipity, and Otherwise

    CrossRef Google Scholar. Stoll NR. National Research Council.

    Human Hookworm Vaccine

    Hotez PJ, Cerami A. Hotez PJ, et al. Zhan B, et al.

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    Expert Rev. Hess JA, et al. Dumonteil E, et al. Bacon KM, et al. Jiang S, et al. Microbes Infect. Hotez P. Health Aff.

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      PLoS Negl. JAMA Psychiatry. Proportion of children 1—14 years of age in the country requiring preventive chemotherapy PC for soil-transmitted helminthiases, worldwide, [Internet]. Distribution of schistosomiasis, worldwide, [Internet]. Hotez 1 2 3 4 5 6 7 Email author 1.